Alice Howland, played by actress Julianne Moor, happily married and mother of three adult children, is a renowned professor of linguistics at Harvard. She receives a huge shock when Alzheimer's disease is diagnosed and she realizes that her carefully built life will change drastically. Slowly but surely she begins to lose control over her own world, while the mutual bonds within the family come under increasing pressure. A frightening, heartbreaking, and inspiring portrait of an independent, strong woman who struggles to remain connected to the person she once was.