The marriage of Angela (Olivia Wilde) and Joe (Seth Rogen) has been in a rut for a while and is characterized by neurotic bickering. Their eccentric upstairs neighbors Hawk (Edward Norton) and Pina (Penélope Cruz) turn out to be particularly active especially at night, to the great annoyance of Joe. When Wanneer Angela invites them for a dinner, Joe sees this as the ultimate opportunity to confront them. What follows is an evening full of unexpected turns, which none of them will soon forget...