FBI agent Will Graham puts himself in the sick minds of serial killers to stay one step ahead of them. Following a traumatic experience, he has retired from active duty, until 'De Tandenfee' emerges—a deranged serial killer who owes his nickname to the bite marks he leaves on his victims. To track him down, Will will reluctantly have to consult an equally disturbed yet brilliant mind, Dr. Hannibal Lecktor.